Grant-in-Aid for Scientific Research on Innovative Areas FY2017-2021Hybrid Catalysis

Yasuhiro Yamashita » Japanese

Affiliation School of Science, The University of Tokyo
Position Associate Professor
Speciality Synthetic Organic Chemistry
Keyword 有機合成化学


In this project, development of hybrid catalyst systems of strong base catalysts and metal catalysts or organocatalysts is focused to achieve efficient activation of stable and easily available organic molecules for stereoselective reactions.


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Original papers

  • "Solid Superbase-Catalyzed Stereoselective 1,4-Addition Reactions of Simple Amides in Batch and Continuous-Flow System"
    Borah, P.; Yamashita, Y.*; Kobayashi, S.*
    Adv. Synth. Catal., 7/3/2019, 361, 3807-3812
  • "Alkyl Potassium-Catalyzed Benzylic C–H Alkylation of Alkylarenes with Alkenes"
    Sato, I.; *Yamashita, Y.; *Kobayashi S.
    Synthesis, 1/2019, 51(01), 240-250
  • "Catalytic alkylation reactions of weakly acidic carbonyl and related compounds using alkenes as electrophiles"
    Yamashita, Y.; Igarashi, R.; Suzuki, H.; *Kobayashi, S.
    Org. Biomol. Chem., 8/22/2018, 16(33), 5969-5972
  • "Catalytic Direct‐type Addition Reactions of Alkylarenes with Imines and Alkenes"
    Yamashita, Y.; Suzuki, H.; Sato, I.; Hirata, T.; *Kobayashi, S.
    Angew. Chem. Int. Ed. , 6/4/2018, 57(23), 6896-6900
  • "Catalytic Addition Reactions of Alkylazaarenes to Vinylsilanes"
    Yamashita, Y.; Minami, K.; *Kobayashi, S.
    Chem. Lett., 5/2018, 47(5), 680-692
  • "Catalytic Carbon–Carbon Bond-Forming Reactions of Weakly Acidic Carbon Pronucleophiles Using Strong Brønsted Bases as Catalysts"
    Yamashita, Y.; *Kobayashi, S.
    Chemistry – A European Journal, 1/2/2018, 24(1), 10-17


  • 「Catalytic enantioselective aldol reactions」 Yamashita, Y.; Yasukawa, T.; Yoo, W.-J.; Kitanosono, T.; *Kobayashi, S., Chemical Society Reviews, 47, 4388-4480, 12, 6/18/2018


  • OMCOS 20
    "Development of Catalytic Carbon–Carbon Bond Forming Reactions of Unactivated Alkylarenes Using Alkaline Metal Catalysts", 口頭発表
    Yamashita, Y.; Kobayashi, S.
    7/21/2019-7/25/2019, Heidelberg, Germany
  • The 1st International Symposium on Hybrid Catalysis for Enabling Molecular Synthesis in Demand
    "Development of Catalytic Carbon–Carbon Bond Forming Reactions of Weakly Acidic Compounds Using Alkaline Metal Base Catalysts", 招待講演
    Yamashita, Y.
    5/30/2019-5/31/2019, 東京, 日本
  • The Ninth International Forum on Chemistry of Functional Organic Chemicals (IFOC-9)
    "Catalytic Addition Reactions of Alkylarenes with Imines and Alkenes", ポスター発表
    Hirata, T.; Yamashita, Y.; Suzuki, H.; Sato, I.; Kobayashi, S.
    11/18/2018-11/19/2018, 東京大学(東京), 日本