Grant-in-Aid for Scientific Research on Innovative Areas FY2017-2021Hybrid Catalysis

Hirofumi Ueda » Japanese

Affiliation Tohoku University, Graduate School of Pharmaceutical Sciences
Position Lecturer
Contact Email
HP http://www.pharm.tohoku.ac.jp/~seizou/index.html
Speciality Synthetic Organic Chemistry
Keyword Total Synthesis, Alkaloids, Domino Reaction
Institute The Pharmaceutical Society of Japan, The Society of Synthetic Organic Chemistry, Japan

Abstract

Our group focuses on natural alkaloids possessing complex and unique skeletons as new drug candidates. In order to establish efficient and divergent synthesis of these complex compounds, we are engaged on development of domino-type synthetic transformations and tandem catalysis, which are able to minimize numbers of steps, reagents and operation time. Finally, we are also interesting new hybrid catalysis developed in this research group and willingly utilize the method in our natural product synthesis.

Achievement

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Original papers

  • "Synthesis of leuconoxine, leuconodine B, and rhazinilam by transformation of melodinine E via 6-hydro-21-dehydroxyleuconolam"
    A. Umehara, H. Ueda, H. Tokuyama
    Tetrahedron, 12/8/2020, 79, 131809
  • "Synthesis of substituted anilines via a gold-catalyzed three-component reaction"
    Ueda, H.; Yamamoto, R.; Yamaguchi, M.; Tokuyama, H.
    Org. Biomol. Chem., 11/2/2020, 19, 765
  • "A Concise Enantioselective Total Synthesis of (–)-Deoxoapodine"
    Yoshida, K.; Okada, K.; Ueda, H.; Tokuyama, H.
    Angew. Chem. Int. Ed., 9/7/2020, 59(51), 23089
  • "Nitrile Synthesis by Aerobic Oxidation of Primary Amines and in situ Generated Imines from Aldehydes and Ammonium Salt with Grubbs Catalyst "
    Utsumi, T.; Noda, K.; Kawauchi, D.; Ueda, H.; Tokuyama, H.
    Adv. Synth. Catal., 6/3/2020, 362(17), 3583
  • "Aerobic Dehydrogenation of N-Heterocycles with Grubbs Catalyst: Its Application to Assisted-Tandem Catalysis to Construct N-Containing Fused Heteroarenes "
    Kawauchi, D; Noda, K.; Komatsu, Y.; Yoshida, K; Ueda, H.; Tokuyama, H.
    Chem. Eur. J., 6/2/2020, 26(68), 15793
  • "Synthesis of Propargylic Ethers by Gold-Mediated Reaction of Terminal Alkynes with Acetals"
    Furuta, M.; Sugiyama, K.; Yamaguchi, M.; Ueda, H.; *Tokuyama, H.
    Chem. Pharm. Bull., 5/8/2019, 67(8), 872-876
  • "Identification of Emetine as a Therapeutic Agent for PulmonaryAarterial Hypertension -A Novel Eeffect of an Old Drug- "
    Siddique,M. A. H.; Satoh, K.; Kurosawa, R.; Kikuchi, N.; Elias-Al-Mamun, M.; Omura, J.; Satoh, T.; Nogi, M.; Sunamura, S.; Miyata, S.; Ueda, H.; Tokuyama, H.; Shimokawa, H.
    Arterioscler. Thromb. Vasc. Biol., 9/19/2019, 39(11), 2367-2385
  • "Construction of Indole Structure on Pyrroloindolines via AgNTf2-Mediated Amination/Cyclization Cascade: Application to Total Synthesis of (+)-Pestalazine B"
    Hakamata, H.; Ueda, H.; *Tokuyama, H.
    Org. Lett., 5/22/2019, 21(11), 4205-4209
  • "Double Functionalization of Styrenes by Cu-mediated Assisted Tandem Catalysis"
    Kawauchi, D.; Ueda, H.; *Tokuyama, H.
    Eur. J. Org. Chem., 2/15/2019, 15, 2056-2060

Review

  • 「Synthetic Studies toward Dimeric Indole Alkaloids Based on Convergent Synthetic Strategy」 *Ueda, H., Chem. Pharm. Bull., 68, 117-128, 2, 2/1/2020

Media

  • Chem. Pharm. Bull誌
    「Synthesis of Propargylic Ethers by Gold-Mediated Reaction of Terminal Alkynes with Acetals」
    5/8/2019
    Chem. Pharm. Bull誌のcover pictureに選出。
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